Table 1.
Pharmacokinetic Parameters of HDP-CDV in Ocular Tissues
| Parameters | Aqueous | Iris | Ciliary Body | Vitreous | Retina | Choroid |
|---|---|---|---|---|---|---|
| R2, adjusted | 0.99 | 0.99 | 0.98 | 0.99 | 0.98 | 0.97 |
| Points used | 3 | 3 | 3 | 3 | 3 | 3 |
| K, day−1 | 0.053 | 0.093 | 0.064 | 0.11 | 0.082 | 0.1 |
| Half-life, d | 13.1 | 7.4 | 10.8 | 6.2 | 8.4 | 6.9 |
| Tmax, d | 3 | 3 | 3 | 1 | 1 | 1 |
| Cmax, ng/mL | 163 | 1,493 | 4,666 | 3,812 | 80,377 | 12,330 |
| Tlast, d | 35 | 35 | 35 | 35 | 35 | 35 |
| AUClast, day · ng/mL | 2,550 | 12,082 | 65,703 | 17,789 | 317,971 | 90,585 |
| MRTINF, pred, d | 18.3 | 9.1 | 14.6 | 6.9 | 7.6 | 7.8 |
K, first-order rate constant of the drug clearance; Cmax, maximum concentration; Tmax, the time at which the concentration was maximum; MRTINF pred, extrapolated and predicted mean residence time; AUC, area under curve.