Fig. 7.

Long-term effects of medial ganglionic eminence (MGE)-neural stem cell (NSC) grafting (a-d) on spontaneous recurrent motor seizures (SRMS) in chronically epileptic rats. The Y-axis in bar charts (a) and (c) denotes the average numbers of seizures per session (4-h block) of observation. Note that MGE-NSC grafting considerably decreases the seizure frequency (a), the duration of individual seizures (b), the severity of seizures (c), and the total time spent in seizures (d). *p < 0.05; **p < 0.01. (e, f) The bar charts show seizure frequency and seizure duration in chronically epileptic animals that received sham-grafting surgery. Sham-grafting surgery does not alter the seizure frequency or the seizure duration in chronically epileptic rats. (Figure reproduced with modifications (Fig. 3), from Waldau et al., Stem Cells 2010;28:1153–1164)