Mean Montgomery-Asberg Depression Rating Scale (MADRS) (A), Hamilton Anxiety Rating Scale (HARS) (B), and Clinical Global Impressions–Improvement (CGI-I) scale (C) scores for the placebo/scopolamine hydrobromide (P/S) group and the scopolamine/ placebo (S/P) group across 8 assessments. Two baseline, 3 block 1, and 3 block 2 assessments are identified in each panel. Because the CGI-I scale reflects change from the first evaluation, no score is associated with assessment 1 (ie, baseline). Error bars represent SE. For each scale, there are significant group × assessment interactions (P<.001 for all).