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Microscopic features of IgG4-related lymphadenopathy, type I. (A) Multicentric Castleman disease-like pattern with interfolicular expansion (H&E stain, ×40). (B) Perivascular sclerosis and hyalinized venules in lymphoid follicles are identified (H&E stain, ×100). (C) The interfollicular area is infiltrated by plasma cells intermixed with collagen fibers (H&E stain, ×400). (D) Many plasma cells are positive for IgG4 (immunohistochemical stain, ×200). IgG4, immunoglobulin G4.
