Table 3B.
Demographics and statistics of glucose and endocrine measures of the subgroup of patients with narcolepsy free of medication compared to a respective control group, matched for gender and age
| Narcolepsy (3 f, 6 m) Mean (SD) | Control (3 f, 6 m) Mean (SD) | P-Value | Effect Size | |
|---|---|---|---|---|
| Age (years) | 30.89 (6.8) | 34.67 (8.1) | 0.30 | −0.51 |
| BMI (kg/m2) | 27.28 (2.3) | 26.66 (2.11) | 0.56 | 0.28 |
| Glucose 0 Minutes (mmol/L) | 93.78 (7.0) | 94.56 (9.6) | 0.85 | −0.09 |
| Glucose 120 Minutes (mmol/L) | 100.78 (36.0) | 96.44 (17.5) | 0.75 | 0.15 |
| AUCi (mg × min/dL) | 3728 (3016) | 4229 (2243) | 0.70 | −0.19 |
| Insulin max. (μU/mL) | 109.05 (36.9) | 111.84 (42.4) | 0.88 | −0.07 |
| Glucose max. (mmol/L) | 146.0 (34.1) | 165.11 (28.1) | 0.21 | −0.61 |
| HOMA2-S | 59.1 (13.3) | 59.9 (11.3) | 0.89 | −0.05 |
| HOMA2-B | 130.48 (22.9) | 128.42 (31.4) | 0.88 | 0.07 |
| ISI | 5.35 (2.74) | 4.14 (0.89) | 0.26 | 0.57 |
| Insgen | 1.94 (1.04) | 1.18 (0.7) | 0.09 | 0.87 |
AUCi, incremental area under the curve of glucose from 0 to 120 minutes; HOMA2, Homeostasis Model Assessment 2 to estimate model derived steady beta cell function (-B) and insulin sensitivity (-S); ISI, Insulin Sensitivity Index from Matsuda et al. (1000 / ([fasting glucose × fasting insulin] × [mean glucose x mean insulin])0.5; Insgen, Insulinogenic Index (insulin 30 min – insulin 0 min) / (glucose 30 min – glucose 0 min); af, female; m, male.