Table 4. Factors predictive of rapid (RVR) and sustained virological response (SVR) to anti-hepatitis C virus therapy.
Univariate nonparametric analysis | Multivariable analysis | |||||||
RVR | SVR | |||||||
Factor | RVR (%) | P | SVR (%) | P | Adjusted OR (CI95) | P | Adjusted OR (CI95) | P |
Plasma HCV RNA | ||||||||
(≤vs.>800000 IU/mL) | 67.6 vs. 25.0 | 0.003 | 82.8 vs. 50.0 | 0.02 | 5.36 (1.04 – 27.81) | 0.04 | 6.68 (1.01 – 47.08) | 0.05 |
LDL-C mg/dL | ||||||||
(≥80 vs.<80) | 70.0 vs. 33.3 | 0.02 | 88.9 vs. 47.4 | 0.008 | 3.08 (0.67 – 14.05) | 0.14 | 3.31 (0.45 – 24.33) | 0.23 |
Cirrhosis | ||||||||
(no vs. yes) | 60.6 vs. 40.0 | 0.12 | 74.2 vs. 62.5 | 0.30 | 2.51 (0.51 – 12.23) | 0.25 | ||
Use of TDF vs. ABV | 54.5 vs. 60.0 | 0.49 | 72.4 vs. 87.5 | 0.35 | n.a. | n.a. | ||
IL28B | ||||||||
(CC vs. CT/TT) | 43.5 vs. 42.1 | 0.26 | 63.2 vs. 68.4 | 0.50 | n.a. | n.a. | ||
Treatment exposition | ||||||||
(≥80% vs.<80%) | n.a. | 81.6 vs. 40.0 | 0.07 | n.a. | 7.81 (0.37 – 161.4) | 0.18 |
TDF: tenofovir. ABV: abacavir. n.a.: not applicable.