Table 5. Probability of the spectrum of rpoB mutations in the INH-resistant mutant and the wildtype parent being identical.

	Probability
strain	method 1 (1-ml)	method 2 (10-ml)
H26	NA	0.60-0.50
H15	NA	0.5
H48	NA	0.40-0.30
H71	NA	<0.001
H103	0.60-0.50	<0.001
2001–2185	0.09-0.08	0.90-0.80
2001-1669	<0.001 *	0.01-0.001 *
2001-1670	0.40-0.30*	<0.001 *

The probability of hypothesis h0_b (the spectrum of rpoB-mutations of the INH-resistant mutant is not different than that of the wildtype parent) determined by X² for all INH-resistant strains for both methods. For all of the tested strains the statistical power of the X² test was reduced due to one or more mutations occurring less than five times. NA: not available, mutants were not obtained for these strains.

*: since both 2001-1669 and 2001-1670 are resistant to INH (via katG-S315T), the spectrum was compared to the only susceptible LAM strain, 9900098. Bold : p_a<0.05, therefore hypothesis is rejected.