Table 1. Early RA patient baseline demographics and associations with response to steroid/methotrexate therapy.
Entire Cohort | NR | MOD/GOOD | NR vs. MOD/GOOD | |
n = 73 | n = 11 | n = 31 | p value | |
Gender (% women) | 69 | 91 | 64 | P = 0.03 (‡) |
Age (median years) | 51 | 59 | 48 | P = 0.071 (φ) |
Smoking (% ever smoked) | 45.7 | 66 | 38.4 | P = 0.245 (‡) |
Smoking (% current smokers) | 25.7 | 22.2 | 26.9 | P = 1.0 (‡) |
CCP titre (mean) | 204 | 229 | 194 | P = 0.539 (φ) |
CCP positive (%) | 86 | 90 | 84 | P = 0.7448 (‡) |
RF titre (mean) | 145 | 192 | 127 | P = 0.156 (φ) |
RF positive (%) | 80 | 80 | 80 | P = 1.00 (‡) |
DAS28ESR baseline | 5.6 | 5.20 | 5.74 | P = 0.44 (φ) |
CD16 expression (mean MFI) | 15.13 | 21.08 | 13.16 | P = 0.0009 (φ) |
A cohort of early RA patients (n = 73) were recruited for investigation. Baseline characteristics of the cohort is summarised in column [Entire cohort]. Patients with EULAR response data at week 14 post-initiation of therapy (n = 42) were furthermore split into non-responders [NR] or moderate/good responders [MOD/GOOD] and baseline characteristics in each subgroup analysed separately. Statistically significant differences between the two EULAR response subgroups [NR vs. MOD/GOOD] were examined. (‡) fishers statistical test (φ) mann-whitney U test.