Table 3. Detection of intratumor variation in BRAF mutation rates via laser capture microdissection.
| Tumor | No. regions dissected | BRAFV600E DNA percentages | Statistical variance (×100) | Presence of heterogeneity1 | ||||
| Dissected region | ||||||||
| 1 | 2 | 3 | 4 | 5 | ||||
| 1 | 5 | 39.4% | 42.8% | 43.6% | 48.1% | 56.1% | 0.419 | Unlikely |
| 2 | 4 | 7.4% | 13.4% | 16.3% | 31.3% | 1.038 | Unlikely | |
| 3 | 3 | 6.7% | 7.9% | 29.0% | 1.575 | Unlikely | ||
| 4 | 3 | 0.0% | 16.8% | 33.4% | 2.787 | Likely | ||
| 5 | 4 | 0.0% | 21.9% | 32.5% | 39.7% | 2.991 | Likely | |
| 6 | 4 | 9.7% | 42.5% | 52.9% | 53.6% | 4.247 | Marked | |
| 7 | 4 | 0.0% | 0.0% | 22.2% | 48.3% | 5.286 | Marked | |
| 8 | 4 | 0.0% | 0.0% | 0.0% | 48.9% | 5.969 | Marked | |
| 9 | 5 | 4.9% | 13.9% | 18.8% | 77.7% | 81.2% | 13.691 | Marked |
1
Qualitative judgment based on variance values, see text for full explanation.