Table 1. Case Study 1.
| Type | Molecule | Function/Comment |
| Input | CD38 | ADP-ribosylcyclase 1, modulator of NAD levels |
| CXCL1 | Growth-regulated protein alpha precursor, chemokine | |
| IL-8 | Interleukin-8, chemotactic cytokine (CXCL8), inflammatory response | |
| IL-1β | Interleukin-1beta, cytokine, inflammatory response | |
| IL-6 | Interleukin-6, cytokine, multiple functions | |
| IL-13 | Interleukin-13, cytokine, multiple functions | |
| IL-24 | Interleukin-24, cytokine, antiproliferative properties | |
| MCP-1 and 2 | Monocyte chemotactic proteins; mitogenic, chemotactic, and inflammatory activity | |
| IFN-γ | Interferon-gamma; antiviral, antiproliferative, and immunoregulatory functions | |
| Nicotinamide (NAM) | Lifespan extension in primary fibroblasts | |
| STC-1 | Stanniocalcin-1; phosphate regulator, up-regulated in nicotinamide microarray experiments | |
| IGF-1 | Insulin-like growth factor 1, downregulated in NAM supplementation studies | |
| SFRP-1 | Secreted frizzled-related protein 1, function unknown, upregulated in NAM supplementation studies | |
| Matrix metalloproteinase | Extracellular proteinases (MMP), involved in extracellular matrix degradation | |
| MMP 3 | MMP, downregulated in NAM supplementation studies, implicated in wound repair, atherosclerosis, and tumor initiation | |
| MMP 12 | Extracellular proteinase, downregulated in NAM supplementation | |
| Serpin B-2/PAI-2 | Degrades elastin, serine or cysteine proteinase inhibitor | |
| Output | Poly(ADP-ribose) | DNA repair and programmed cell death |
Storytelling inputs and outputs used to explore combinatorial relationships. All input molecules listed are extracellular except CD38, which is bound to the outer membrane.