Table 7. A story between PubMed IDs 12389004 (nicotinamide) and 11420111 (poly-ADP-ribose).
PubMed ID | Title (followed by the Substance MeSH) | Chosen Sentence |
12389004 | (nicotinamide): Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes. | STUDY DESIGN: PBEF was immunolocalized in the fetal membranes from early pregnancy , at preterm , and at term. |
16701870 | (NF-kappa B): Pre-B-cell colony-enhancing factor (PBEF/Visfatin) gene expression is modulated by NF-kappaB and AP-1 in human amni otic epithelial cells. | These data show that an inflammatory stimulus in the fetal membranes inducing NF-kappaB and AP-1 would up-regulate PBEF as well as IL-8. |
12748173 | (NF-kappa B): Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB. | Indomethacin , a cyclooxygenase inhibitor , partially inhibited IL-8 release and the promoter binding of AP-1 and NF-IL-6 , but not NF-kappaB. |
10494847 | (NF-kappa B): A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation. | Here we show that poly (ADP ribose) polymerase (PARP) is required for specific NF-kappaB transcriptional activation in vivo. |
11420111 | (poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone. | Crithidia fasciculata poly (ADP-ribose) polymerase (PARP) has been isolated and partially purified. |
This story connects nicotinamide to PAR/PARP and is more interesting when the individual papers in the story are observed, especially in light of NAM lifespan extension. The focus of the paper with PubMed ID 16701870 is actually Nampt, the rate-limiting enzyme in the NAD salvage pathway. This enzyme also acts as a cytokine and is modulated by NF-kB activity, which is known to be dependent on PARP. Considering all these facts, one can build a hypothesis that PARP modulates Nampt.