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. 2012 Jan 3;7(1):e29660. doi: 10.1371/journal.pone.0029660

Figure 6. In vivo angiogenesis assay.

Figure 6

Effects of aPL with or without LMWHs on angiogenesis process in vivo. Endothelial cells in the angioreactors were incubated with FITC-lectin, recovered and analyzed for FITC-lectin by fluorescence spectrometry. The analysis demonstrated reduced fluorescence (45%) in angioreactors containing aPL (50 µg/ml) compared with the positive controls. Tinzaparin or enoxaparin were able to completely reverse this angiogenesis inhibition. Results are means ± SE (n = 5 mice per group) from three independent experiments and expressed as RFU (Relative Fluorescent Units), % of control. CTR+: positive control; T: tinzaparin; E: enoxaparin; I.U.: International Units; ζ: P<0.05 compared with CTR; *: P<0.05 compared with aPL treatment.