Skip to main content
. 2012 Jan 3;7(1):e29745. doi: 10.1371/journal.pone.0029745

Figure 8. Schematic representation of the IL-11 mediated signaling and gene expression in JEG-3 and HTR-8/SVneo cells.

Figure 8

IL-11 treatment to JEG-3 cells led to the activation of STAT1/3, which after dimerization moves into the nucleus. The activation of STAT3 was associated with a transient activation of ERK1/2. Activation of STAT3(tyr705) is associated with its nuclear localization. In effect to these, an increase in the expression of pro-invasive molecules like Jun, Fos, MUC1, PDPN, MMP23B etc have been observed. In HTR-8/SVneo cells, IL-11 treatment increases the activation of STAT1(tyr701) and STAT3(tyr705) while, decreases the activation of ERK1/2. The increase in p-STAT3(tyr705) was associated with its nuclear localization within 10 min of IL-11 treatment. However, upon IL-11 treatment, there was nuclear co-localization of p-STAT3(tyr705) with its inhibitory factor PIAS1/3. This could be the reason for the decrease in the expression of Fos, MMP2, MMP3, MMP9 and MMP23B. (Solid arrows show the confirmed findings while, dotted arrows show the hypothetical links, which needs to be validated. Name of genes written in italics have been confirmed at the RNA level while, other have been confirmed at the protein level.).