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. 2012 Jan 3;6(1):e1443. doi: 10.1371/journal.pntd.0001443

Table 1. Putative targets of SmMef2.

Putative gene type (name) Smp number Binding site sequence Distance upstream Gene ID (NCBI)
actin* Smp_046590 cttttattaa 582 8349760
actin* # Smp_077850 CTATTTTTAG 3565 8345287
actin* Smp_161920 cttattatag, cttaatttag 2013, 3694 8349219
BMP antagonist noggin* Smp_099440 ctaattataa 31 8351146
crp1/csrp1/crip1* # Smp_087250 CTAAATATAG 1921 8355365
DNA replication licensing factor MCM7# Smp_032500 CTAAAAATAG 455 8348621
four and a half LIM domains* Smp_048560 ctataaataa, ctattaataa 2587, 4712 8341782
four and a half LIM domains* # Smp_143130 ctttattag, cttttattag, cttaaaatag, CTAAAAATAG 169, 2013, 4436, 4713 8351888
GLUT4 Smp_050640 ctaaaaataa, ctttttatag 230, 600 8343690
gsx family homeobox protein* Smp_138140 ctatttataa 1382 8347764
myosin XV Smp_127510 ctattattaa 1785 8353008
netrin# Smp_146840 CTAAATATAG, ctaatatta 1403, 4948 8348295
netrin Smp_151310 ctaatattag, ctaattttaa 1782, 2823 8340778
semaphorin 5-related# Smp_158550 CTAAATATAG 3459 8343948
TGF beta family* Smp_063190 cttaaaatag, ctatatttaa 310, 1172 8347411
tropomyosin# Smp_022170 CTAAATATAG 791 8343498
tropomyosin Smp_044010 ctttaattag, ctttttttag 1403, 4077 8350309
tropomyosin# Smp_085290 CTATTATTAG 1775 8347052
tubulin beta chain* Smp_078040 ctaaaaataa 4193 8353635
tubulin beta chain* Smp_079960 ctaaatttaa 1099 8347203
tubulin beta chain* Smp_079970 ctatttttaa, ctaaatttaa 1777, 2811 8347204
tubulin beta chain* Smp_035760 ctatttttaa 2832 8345905
tubulin delta chain Smp_154880 cttaatttag 3246 8342529
tubulin epsilon chain# Smp_028360 CTAATATTAG 948 8343061
WNT related* # Smp_167140 ctataaataa, CTAATAATAG, ctttatttag 456, 1387, 4817 8352146
WNT related* # Smp_152900 CTATAAATAG 433 8345780

KEY.

*:blasted from D. melanogaster gene with know Mef2 binding sites.

#

: contains upstream sequence conforming to the strict Mef2 consensus.

Schistosome homologs of known Drosophila Mef2 transcriptional targets were individually screened for Mef2 binding sites within 5000 base pairs of the translation start site. Genes were screened for strong consensus (capital letters, highlighted in grey: CTAWWWWTAG) and weak consensus sequences (lower case letters: CTWWWWWTAG or CTAWWWWTAR). Upstream distances from the start codons are noted in base pairs.