Table 1. Putative targets of SmMef2.
Putative gene type (name) | Smp number | Binding site sequence | Distance upstream | Gene ID (NCBI) |
actin* | Smp_046590 | cttttattaa | 582 | 8349760 |
actin* # | Smp_077850 | CTATTTTTAG | 3565 | 8345287 |
actin* | Smp_161920 | cttattatag, cttaatttag | 2013, 3694 | 8349219 |
BMP antagonist noggin* | Smp_099440 | ctaattataa | 31 | 8351146 |
crp1/csrp1/crip1* # | Smp_087250 | CTAAATATAG | 1921 | 8355365 |
DNA replication licensing factor MCM7# | Smp_032500 | CTAAAAATAG | 455 | 8348621 |
four and a half LIM domains* | Smp_048560 | ctataaataa, ctattaataa | 2587, 4712 | 8341782 |
four and a half LIM domains* # | Smp_143130 | ctttattag, cttttattag, cttaaaatag, CTAAAAATAG | 169, 2013, 4436, 4713 | 8351888 |
GLUT4 | Smp_050640 | ctaaaaataa, ctttttatag | 230, 600 | 8343690 |
gsx family homeobox protein* | Smp_138140 | ctatttataa | 1382 | 8347764 |
myosin XV | Smp_127510 | ctattattaa | 1785 | 8353008 |
netrin# | Smp_146840 | CTAAATATAG, ctaatatta | 1403, 4948 | 8348295 |
netrin | Smp_151310 | ctaatattag, ctaattttaa | 1782, 2823 | 8340778 |
semaphorin 5-related# | Smp_158550 | CTAAATATAG | 3459 | 8343948 |
TGF beta family* | Smp_063190 | cttaaaatag, ctatatttaa | 310, 1172 | 8347411 |
tropomyosin# | Smp_022170 | CTAAATATAG | 791 | 8343498 |
tropomyosin | Smp_044010 | ctttaattag, ctttttttag | 1403, 4077 | 8350309 |
tropomyosin# | Smp_085290 | CTATTATTAG | 1775 | 8347052 |
tubulin beta chain* | Smp_078040 | ctaaaaataa | 4193 | 8353635 |
tubulin beta chain* | Smp_079960 | ctaaatttaa | 1099 | 8347203 |
tubulin beta chain* | Smp_079970 | ctatttttaa, ctaaatttaa | 1777, 2811 | 8347204 |
tubulin beta chain* | Smp_035760 | ctatttttaa | 2832 | 8345905 |
tubulin delta chain | Smp_154880 | cttaatttag | 3246 | 8342529 |
tubulin epsilon chain# | Smp_028360 | CTAATATTAG | 948 | 8343061 |
WNT related* # | Smp_167140 | ctataaataa, CTAATAATAG, ctttatttag | 456, 1387, 4817 | 8352146 |
WNT related* # | Smp_152900 | CTATAAATAG | 433 | 8345780 |
KEY.
*:blasted from D. melanogaster gene with know Mef2 binding sites.
: contains upstream sequence conforming to the strict Mef2 consensus.
Schistosome homologs of known Drosophila Mef2 transcriptional targets were individually screened for Mef2 binding sites within 5000 base pairs of the translation start site. Genes were screened for strong consensus (capital letters, highlighted in grey: CTAWWWWTAG) and weak consensus sequences (lower case letters: CTWWWWWTAG or CTAWWWWTAR). Upstream distances from the start codons are noted in base pairs.