Table 4. Amblyopic Eye Visual Acuity Over Time.
| Baseline Visit | 9-Week Visit | 18-Week Visit | Best Acuity 18-weeks or Later* | |||||
|---|---|---|---|---|---|---|---|---|
| Combined | Strabismus | Combined | Strabismus | Combined | Strabismus | Combined | Strabismus | |
| N= 94 | N= 52 | N=86 | N=42 | N=86 | N=43 | N=86 | N=43 | |
| Change from Baseline | ||||||||
| ≥3 lines worse | 1 (1%) | 0 | 0 | 0 | 0 | 0 | ||
| 2 lines worse | 3 (3%) | 1 (2%) | 2 (2%) | 0 | 2 (2%) | 0 | ||
| 1 line worse | 3 (3%) | 0 | 2 (2%) | 0 | 2 (2%) | 0 | ||
| 0 lines | 14 (16%) | 4 (10%) | 10 (12%) | 3 (7%) | 10 (12%) | 3 (7%) | ||
| 1 line better | 16 (19%) | 7 (17%) | 13 (15%) | 2 (5%) | 10 (12%) | 2 (5%) | ||
| 2 lines better | 25 (29%) | 10 (24%) | 16 (19%) | 11 (26%) | 15 (17%) | 10 (23%) | ||
| ≥3 lines better | 24 (28%) | 20 (48%) | 43 (50%) | 27 (63%) | 47 (55%) | 28 (65%) | ||
| Mean (SD) logMAR lines change | 1.5 (1.9) | 2.5 (1.9) | 2.3 (1.8) | 3.2 (1.9) | 2.5 (1.9) | 3.3 (2.1) | ||
|
| ||||||||
| Distribution of Visual Acuity | ||||||||
| 20/125 or worse (≥ 0.8 logMAR) | 24 (26%) | 16 (31%) | 14 (16%) | 6 (14%) | 8 (9%) | 3 (7%) | 7 (8%) | 3 (7%) |
| 20/100 (0.7 logMAR) | 17 (18%) | 6 (12%) | 3 (3%) | 3 (7%) | 8 (9%) | 5 (12%) | 7 (8%) | 5 (12%) |
| 20/80 (0.6 logMAR) | 16 (17%) | 8 (15%) | 12 (14%) | 2 (5%) | 13 (15%) | 1 (2%) | 14 (16%) | 1 (2%) |
| 20/63 (0.5 logMAR) | 14 (15%) | 7 (13%) | 12 (14%) | 4 (10%) | 8 (9%) | 3 (7%) | 8 (9%) | 3 (7%) |
| 20/50 (0.4 logMAR) | 13 (14%) | 11 (21%) | 15 (17%) | 5 (12%) | 11 (13%) | 3 (7%) | 8 (9%) | 3 (7%) |
| 20/40 (0.3 logMAR) | 10 (11%) | 4 (8%) | 7 (8%) | 7 (17%) | 4 (5%) | 8 (19%) | 6 (7%) | 7 (16%) |
| 20/32 (0.2 logMAR) | 0 | 0 | 12 (14%) | 11 (26%) | 15 (17%) | 9 (21%) | 16 (19%) | 8 (19%) |
| 20/25 (0.1 logMAR) | 0 | 0 | 8 (9%) | 1 (2%) | 10 (12%) | 8 (19%) | 8 (9%) | 9 (21%) |
| 20/20 (0.0 logMAR) | 0 | 0 | 3 (3%) | 3 (7%) | 9 (10%) | 2 (5%) | 12 (14%) | 3 (7%) |
| 20/16 (-0.1 logMAR) | 0 | 0 | 0 | 0 | 0 | 1 (2%) | 0 | 1 (2%) |
| Mean (SD) logMAR | 0.64 (0.24) | 0.65 (0.26) | 0.47 (0.30) | 0.40 (0.26) | 0.41 (0.29) | 0.33 (0.25) | 0.39 (0.29) | 0.32 (0.26) |
| Snellen Equivalent | 20/80-2 | 20/80-2 | 20/63+1 | 20/50 | 20/50-1 | 20/40-1 | 20/50+1 | 20/40-1 |
|
| ||||||||
| Distribution of IOD | ||||||||
| -1 line (fellow eye worse) | 0 | 0 | 1 (1%) | 0 | 1 (1%) | 0 | 1 (1%) | 0 |
| 0 lines | 0 | 0 | 3 (3%) | 5 (12%) | 5 (6%) | 5 (12%) | 8 (9%) | 7 (16%) |
| +1 line (amblyopic eye worse) | 0 | 0 | 7 (8%) | 8 (19%) | 18 (21%) | 12 (28%) | 16 (19%) | 11 (26%) |
| +2 lines (amblyopic eye worse) | 0 | 0 | 16 (19%) | 9 (21%) | 10 (12%) | 8 (19%) | 10 (12%) | 8 (19%) |
| +3 lines (amblyopic eye worse) | 24 (26%) | 17 (33%) | 16 (19%) | 7 (17%) | 12 (14%) | 8 (19%) | 15 (17%) | 7 (16%) |
| ≥ +4 lines (amblyopic eye worse) | 70 (74%) | 35 (67%) | 43 (50%) | 13 (31%) | 40 (47%) | 10 (23%) | 36 (42%) | 10 (23%) |
| Mean (SD) logMAR lines | 5.4 (2.4) | 4.9 (2.2) | 4.2 (2.8) | 2.9 (2.4) | 3.7 (2.8) | 2.7 (2.3) | 3.5 (2.8) | 2.6 (2.4) |
| Proportion Resolve** | - | - | 13% | 31% | 28% | 40% | 29% | 42% |
*
Visit at which best amblyopic eye acuity achieved at 18-weeks or later for those that continued on spectacles alone
**
Amblyopic eye visual acuity is within 1 line of fellow eye acuity at the same visit
SD = standard deviation; logMAR = logarithm of the minimum angle of resolution; IOD = inter-ocular difference