Table 2.
Haplotypic association between 3 GABRG1 SNPs (A, D, and F) and AD in African Americans.
| Haplotype | ADs | Controls | Odds Ratio | 95% CI | ||||
|---|---|---|---|---|---|---|---|---|
| Name | ADF | haplotype (N) |
E(freq) | haplotype (N) |
E(freq) | p-value | ||
| G1-1 | TGC | 234 | 0.308 | 157 | 0.310 | 1 | 1 | (0.74-1.34) |
| G1-2 | TGT | 200 | 0.263 | 134 | 0.265 | 1 | 1 | (0.74-1.36) |
| G1-3 | CAT | 144 | 0.189 | 116 | 0.229 | 0.292 | 0.83 | (0.60-1.16) |
| G1-4 | CGT | 106 | 0.139 | 50 | 0.099 | 0.080 | 1.42 | (0.95-2.15) |
| G1-5 | CGC | 42 | 0.055 | 28 | 0.055 | 1 | 1.00 | (0.58-1.76) |
|
| ||||||||
| 0.954 | 0.958 | |||||||
The p-value for each haplotype was generated by the Fisher exact test. The odds ratio was calculated with haplotype G1-1 as reference.
Global p-value = 0.1701 (df=4, χ2=6.417)
*
Significance at threshold 0.01 based on Bonferroni correction correspond to 0.05/5