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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Hepatology. 2012 Feb;55(2):609–621. doi: 10.1002/hep.24713

Figure 1. Premature onset of age-related pathology in Ercc1−/Δ mouse liver.

Figure 1

(A) Hematoxylin and eosin (H&E) stained liver sections from 7 wk, 23 wk, and 34 mth-old WT mice, and Ercc1−/Δ littermates (10X). The bottom right panel is a high magnification (40X) image of Ercc1−/Δ liver (23 wk) illustrating inflammatory infiltrate (black arrows), abnormal nuclei with inclusion (green arrows) and dead hepatocytes (blue arrows).

(B) Masson’s trichrome stained liver sections. Insets (40X) in the bottom right panel show perisinusoidal fibrosis in Ercc1−/Δ and old WT liver samples.

(C) LipidTOX™ stain of liver sections to detect neutral lipids (20X).

(D) Immunofluorescence detection of desmin and α-SMA, markers of hepatic stellate cells and their activation, respectively, in frozen liver sections (20X).