Table 2.
In vivo distribution of i.p. injected 177Lu-RICs in athymic mice bearing i.p. LS-174T tumor xenografts.
| 177Lu-Trastuzumab | 177Lu-HuIgG | |||||
|---|---|---|---|---|---|---|
| Tissue | 24 h | 72 h | 24 h | 72 h | ||
| Blood | 10.47 ± 9.19 | 10.15 ± 6.27 | 16.8 ± 2.60 | 5.13 ± 3.17 | ||
| Tumor | 13.44 ± 11.52 | 31.70 ± 16.20 | 5.84 ± 1.27 | 5.52 ± 4.92 | ||
| Liver | 4.83 ± 3.63 | 6.11 ± 3.33 | 6.76 ± 1.01 | 2.95 ± 2.06 | ||
| Spleen | 6.81 ± 5.66 | 10.63 ± 6.37 | 6.67 ± 1.17 | 4.22 ± 2.42 | ||
| Kidney | 4.46 ± 3.45 | 5.05 ± 1.69 | 7.07 ± 1.25 | 2.46 ± 1.29 | ||
| Lungs | 4.81 ± 3.84 | 4.30 ± 2.17 | 7.48 ± 1.70 | 2.28 ± 1.24 | ||
| Heart | 3.60 ± 2.97 | 3.59 ± 1.80 | 6.01 ± 1.23 | 1.70 ± 1.03 | ||
| Femur | 1.96 ± 1.58 | 2.54 ± 1.05 | 2.72 ± 0.68 | 1.19 ± 0.62 | ||
The values presented are the average percentage injected dose per gram with the standard deviations.