Figure 10.

Tertiary structure of MEPE and the positive selected sites. The sites showing positive selection in at least two different analyses (purple sticks, three letters amino acid code) and the sites clustered showing positive selection in at least one analysis (close up circles, one letter amino acid code). The principal domains, RGD, SGDG and ASARM are also expanded and circled, as are the three "new" motifs (SEASEN, LNXEXS and ENT) showing positive selection. The secondary structure obtained is defined according to the code of colors described in the picture.