Table 3.
The association between circulating molecules and mammographic breast density (N=238), Wisconsin Breast Density Study, 2008-2009.
| Hormone | Linear regression of square root percent breast density on molecule levels | Mean percent density by molecule quartile (95% Confidence Interval)* | Ptrend | |||||
|---|---|---|---|---|---|---|---|---|
| β coefficient | SE (β) | P | Q1 | Q2 | Q3 | Q4 | ||
| 25(OH)D (ng/mL) | ||||||||
| Age and season adjusted | 0.018 | 0.009 | 0.05 | 11.3 (9.0, 13.9) | 13.5 (10.9, 16.3) | 12.2 (9.7, 15.0) | 15.6 (12.7, 18.8) | 0.07 |
| Age, season, and BMI adjusted | -0.004 | 0.009 | 0.65 | 13.7 (11.3, 16.4) | 14.0 (11.6, 16.6) | 11.2 (9.1, 13.6) | 13.4 (11.1, 16.1) | 0.52 |
| Multivariable-adjusted† | -0.004 | 0.009 | 0.68 | 13.6 (11.3, 16.2) | 14.3 (11.9, 16.9) | 11.2 (9.1, 13.5) | 13.3 (11.0, 15.9) | 0.49 |
| PTH (pg/mL) | ||||||||
| Age and season adjusted | -0.010 | 0.005 | 0.05 | 16.0 (13.1, 19.2) | 12.2 (9.7, 15.0) | 12.8 (10.2, 15.6) | 11.4 (8.9, 14.2) | 0.05 |
| Age, season, and BMI adjusted | -0.005 | 0.004 | 0.27 | 14.9 (12.4, 17.7) | 12.8 (10.5, 15.4) | 12.0 (9.8, 14.5) | 12.5 (10.2, 15.2) | 0.18 |
| Multivariable-adjusted† | -0.003 | 0.004 | 0.48 | 14.9 (12.5, 17.6) | 12.3 (10.0, 14.7) | 12.3 (10.1, 14.7) | 12.8 (10.5, 15.4) | 0.27 |
| Calcium (mg/dL) | ||||||||
| Age and season adjusted | 0.004 | 0.045 | 0.93 | 11.7 (9.2, 14.5) | 13.1 (10.4, 16.0) | 13.6 (10.9, 16.6) | 14.0 (11.2, 17.0) | 0.25 |
| Age, season, and BMI adjusted | -0.020 | 0.041 | 0.62 | 12.8 (10.5, 15.5) | 12.6 (10.3, 15.2) | 13.0 (10.6, 15.5) | 13.8 (11.4, 16.5) | 0.57 |
| Multivariable-adjusted† | -0.016 | 0.039 | 0.69 | 12.7 (10.4, 15.3) | 12.5 (10.3, 15.1) | 13.2 (10.9, 15.8) | 13.7 (11.3, 16.3) | 0.53 |
| IGF-1 (ng/mL) | ||||||||
| Age and season adjusted | 0.003 | 0.002 | 0.15 | 11.9 (9.4, 14.7) | 13.3 (10.8, 16.1) | 11.9 (9.4, 14.7) | 15.1 (12.4, 18.2) | 0.11 |
| Age, season, and BMI adjusted | 0.000 | 0.002 | 0.87 | 13.6 (11.1, 16.2) | 13.2 (11.0, 15.7) | 11.6 (9.4, 14.1) | 13.8 (11.5, 16.4) | 0.90 |
| Multivariable-adjusted† | -0.001 | 0.002 | 0.67 | 14.2 (11.8, 16.9) | 12.6 (10.4, 15.0) | 11.8 (9.6, 14.2) | 13.7 (11.4, 16.2) | 0.74 |
| IGFBP-3 (μg/mL) | ||||||||
| Age and season adjusted | -0.041 | 0.102 | 0.69 | 13.7 (11.0, 16.7) | 11.7 (9.3, 14.4) | 14.4 (11.7, 17.5) | 12.5 (10.0, 15.3) | 0.90 |
| Age, season, and BMI adjusted | -0.042 | 0.090 | 0.64 | 14.2 (11.8, 16.8) | 11.5 (9.4, 13.9) | 13.3 (11.0, 15.9) | 13.3 (11.0, 15.9) | 0.94 |
| Multivariable-adjusted† | -0.063 | 0.088 | 0.48 | 14.3 (11.9, 16.9) | 11.6 (9.5, 13.9) | 13.5 (11.2, 16.1) | 13.0 (10.8, 15.4) | 0.77 |
| IGF-1/IGFBP-3 molar ratio | ||||||||
| Age and season adjusted | 7.5 | 3.3 | 0.02 | 11.9 (9.5, 14.7) | 11.3 (8.9, 13.9) | 13.7 (11.0, 16.6) | 15.6 (12.7, 18.7) | 0.04 |
| Age, season, and BMI adjusted | 0.5 | 3.1 | 0.86 | 14.1 (11.7, 16.8) | 11.4 (9.2, 13.7) | 13.1 (10.7, 15.6) | 13.9 (11.5, 16.5) | 0.83 |
| Multivariable-adjusted† | -0.1 | 3.0 | 0.97 | 14.4 (12.0, 17.0) | 11.6 (9.5, 13.9) | 12.5 (10.2, 14.9) | 13.9 (11.5, 16.5) | 0.96 |
| Retinol (ng/mL) | ||||||||
| Age and season adjusted | 0.000 | 0.430 | 0.99 | 15.0 (12.2, 18.2) | 11.0 (8.6, 13.6) | 14.5 (11.8, 17.5) | 11.9 (9.4, 14.8) | 0.44 |
| Age, season, and BMI adjusted | 0.049 | 0.382 | 0.90 | 15.3 (12.8, 18.0) | 10.7 (8.6, 13.0) | 13.5 (11.1, 16.1) | 13.0 (10.6, 15.7) | 0.55 |
| Multivariable-adjusted† | 0.070 | 0.373 | 0.85 | 15.8 (13.3, 18.5) | 10.4 (8.5, 12.6) | 12.9 (10.7, 15.4) | 13.4 (11.0, 16.1) | 0.49 |
SE, standard error; BMI, body mass index.
*
Mean percent density displayed is reverse transformed from model of square root density; quartile cut-points are described in Table 2.
†
Adjusted for age, body mass index, parity, family history of breast cancer, vigorous physical activity, and smoking.