Table 1.
18F-FDG in different BAT regions in the rat
| BAT type |
Control
a
(kBq/cm 3 /(MBq/kg)) |
CL316,243
a
(kBq/cm 3 /(MBq/kg)) |
Ratio (CL/control) |
|---|---|---|---|
| Interscapular | 1.8 ± 0.8 | 22.7 ± 15 | 12.6 |
| Cervical | 1.7 ± 0.4 | 16.3 ± 6.2 | 9.6 |
| Periaortic | 2.5 ± 1.1 | 23.2 ± 11.6 | 9.3 |
| Intercostal | NA | 9.7 ± 2.2 | NA |
aMean ± SD, n = 3 measured in PET/CT experiments with regions of BAT identified in PET/CT images as shown in Figure 1c; NA, the regions of intercostal BAT in the control animals were unidentifiable due to their small size and very low activity; BAT, brown adipose tissue; CL316,243, (R, R)-5-[2-[2,3-(3-chlorphenyl)-2-hydroxyethyl-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate, disodium salt.