Table 4.

Gene Set Enrichment Analysis to identify functional groups from CDEP identified genes.

Functions (source)	Annotated genes	FDR
ECM-receptor interaction (KEGG)	COL4A2,COL4A1,TNC,COL3A1,COL5A2,COL5A1,COL6A3,COL1A2,COL1A1,LAMB1,COL11A1,THBS2, FN1,SPP1	1.84 × 10-8
Focal adhesion (KEGG)	CAV1,COL4A2,COL4A1,TNC,COL3A1,COL5A2,COL5A1,MYL9,VEGFC,VEGFA,COL6A3,COL1A2, COL1A1,LAMB1,THBS2,COL11A1,FN1,SPP1	2.02 × 10-7
Blood vessel development (GO)	PLAT,CAV1,IL8,COL3A1,COL15A1,COL5A1,VEGFC,APOB,APOE,CTGF,VEGFA,COL1A2,SEMA3C,LOX,COL1A1,CYR61	1.10 × 10-5
Immune response (GO)	CXCL1,POU2AF1,CCL2,BST2,CXCL3,IGJ,CXCL2,CXCL9,IL32,IFI44L,CCL5,CXCL11,HLA-DMA, HLA-DQA1,PSMB8,CXCL10,PSMB9,CXCL13,TAP1,DEFB1,GBP1	2.06 × 10-6
Inflammatory response (GO)	CXCL1,CCL2,NMI,CXCL3,CXCL2,CXCL9,ANXA1,IDO1,CXCL11,CCL5,CXCL10,FOS,SAA2,CXCL13	5.95 × 10-5

The functional enrichment for the genes identified as consistently differentially expressed between primary and metastatic cancers.