Fig. 2.

PI3K inhibition exacerbates the pressor response elicited by central CB₁R activation. Time-course changes in mean arterial pressure (ΔMAP; A and C) and heart rate (ΔHR; B and D) evoked by intracisternal WIN55,212-2 (WIN55; 7.5 μg/rat, A and B or 15 μg/rat, C and D) in conscious rats pretreated, 30 min earlier, with the PI3K inhibitor wortmannin (Wort; 0.4 μg/rat i.c.) or an equal volume of its vehicle. Values are mean ± S.E.M. of five to eight observations. *, P < 0.05 versus control (Veh); #, P < 0.05 comparing Wort + WIN55 data with Veh + WIN55. The vehicle (Veh) or Wort + Veh alone (shown in A and B) were also used for statistical comparisons for data shown in C and D.