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Representative tracings depicting the changes in AP and HR elicited by intracisternal WIN55,212-2 (15 μg/rat) in conscious animals pretreated with vehicle (A), the PI3K inhibitor wortmannin (Wort; 0.4 μg/rat) (B), or the MEK/ERK1/2 inhibitor PD98059 (PD98; 5 μg/rat) (C).
