TABLE 1.

Baseline MAP (mm Hg) and HR (bpm) values before and after pretreatment with different drugs that were administered before WIN55,212-2 or its vehicle

Values are means ± S.E.M.

Treatment	n	MAP		HR
		Before	After	Before	After
Vehicle + vehicle	6	115.0 ± 6.0	113.3 ± 5.0	395 ± 12	400 ± 12
Vehicle + 7.5 μg WIN55,212-2	6	111.3 ± 3.0	108.0 ± 5.0	375 ± 10	350 ± 11
Vehicle + 15 μg WIN55,212-2	8	113.3 ± 5.0	115.0 ± 3.0	370 ± 10	368 ± 17
Wortmannin + vehicle	5	112.0 ± 6.0	117.0 ± 6.0	356 ± 15	376 ± 15
Wortmannin + 7.5 μg WIN55,212-2	8	112.0 ± 6.0	111.0 ± 5.0	360 ± 11	380 ± 10
Wortmannin + 15 μg WIN55,212-2	8	111.3 ± 3.0	112.0 ± 3.0	375 ± 10	363 ± 13
PD98059 + vehicle	5	113.0 ± 4.0	110.0 ± 4.0	398 ± 16	390 ± 20
PD98059 + 15 μg WIN55,212-2	8	117.0 ± 6.0	115.0 ± 4.0	400 ± 12	410 ± 12