Fig. 4.

SKA-31 increases the whole-cell SK current amplitude in freshly isolated guinea pig DSM cells. A, representative recording illustrating that SKA-31 (10 μM) increased the whole-cell SK currents evoked by activation of VDCCs caused by membrane depolarization from −70 to +10 mV for 100 ms. Bar graph shows the summary data for the stimulatory effect of SKA-31 on whole-cell Ca²⁺-activated outward K⁺ currents (n = 10; N = 9; **, P < 0.005). B, representative recording illustrating that SKA-31 (10 μM)-induced whole-cell Ca²⁺-activated outward K⁺ currents were suppressed by 1 μM apamin. Bar graph shows the summary data for the stimulatory effect of SKA-31 on whole-cell outward K⁺ currents that were inhibited by 1 μM apamin (n = 10; N = 9; **, P < 0.005).