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. 2012 Jan;340(1):114–123. doi: 10.1124/jpet.111.186213

Fig. 7.

Fig. 7.

SK channel pharmacological activation with SKA-31 significantly reduces the nerve-evoked contractions in guinea pig DSM isolated strips. A, representative recordings of EFS-induced contraction (stimulation frequency 0.5–50 Hz at 3-min intervals) in the absence of SKA-31 (control), 35 min after application of SKA-31, and after washout of SKA-31. B, frequency-response curves illustrating a decrease in the amplitude of EFS-induced contractions after application of 10 μM SKA-31 (n = 7; N = 7; ***, P < 0.005; **, P < 0.01; *, P < 0.05). Washout of SKA-31 caused a partial recovery on the amplitude of EFS-induced contractions (n = 6; N = 6; ###, P < 0.005; ##, P < 0.01; #, P < 0.05). The maximal contraction amplitude at EFS frequency of 50 Hz under control conditions was taken to be 100%. Data are means ± S.E.M.