Table 5.
Common biological processes
| Tissue combination | Biological process |
|---|---|
| Kidney cortex-kidney medulla | Amiloride transport |
| Amino acid transport | |
| Bone remodeling | |
| Canalicular bile acid transport | |
| Choline metabolism | |
| Negative regulation of cell adhesion | |
| Negative regulation of enzyme activity | |
| Positive regulation of actin filament polymerization | |
| Protection from natural killer cell mediated cytotoxicity | |
| Regulation of hormone secretion | |
| Transport | |
| Kidney cortex-liver | Acetyl-CoA metabolism |
| Cytolysis | |
| Response to sterol depletion | |
| Retinoid metabolism | |
| Steroid biosynthesis | |
| Thermoregulation | |
| Kidney cortex-lung | Cellular response to starvation |
| Cytoskeleton organization and biogenesis | |
| Fatty acid oxidation | |
| Patterning of blood vessels | |
| Positive regulation of glucose import | |
| Positive regulation of lipid metabolism | |
| Protein folding | |
| Regulation of transcription from RNA polymerase II promoter | |
| Kidney cortex-spleen | Regulation of axon extension |
| Regulation of neuronal synaptic plasticity | |
| Response to oxidative stress | |
| Ubiquitin-dependent protein catabolism | |
| Kidney medulla-liver | Digestion |
| Kidney medulla-lung | Cell migration |
| Cell-matrix adhesion | |
| Cellular defense response | |
| Positive regulation of angiogenesis | |
| Positive regulation of neurotransmitter secretion | |
| Regulation of locomotion | |
| Regulation of long-term neuronal synaptic plasticity | |
| Response to hypoxia | |
| Synaptic vesicle transport | |
| Kidney medulla-spleen | Cartilage condensation |
| Central nervous system development | |
| Complement activation; alternative pathway | |
| Neuropeptide signaling pathway | |
| Positive regulation of small GTPase mediated signal transduction | |
| Response to nutrient | |
| S-adenosylmethionine biosynthesis | |
| Liver-lung | Embryonic heart tube development |
| Fatty acid metabolism | |
| Metabolism | |
| Liver-spleen | Negative regulation of signal transduction |
| Regulation of cell growth | |
| Lung-spleen | Iron ion homeostasis |
| Peptidoglycan metabolism | |
| Response to biotic stimulus | |
| Kidney cortex-kidney medulla-lung | Negative regulation of apoptosis |
| Kidney cortex-kidney medulla-spleen | Defense response |
| Kidney cortex-liver-lung | Acute-phase response |
| Complement activation | |
| Lipid metabolism | |
| Kidney cortex-lung-spleen | Response to glucose stimulus |
| Kidney medulla-lung-spleen | Positive regulation of non-apoptotic programmed cell death |
| Liver-lung-spleen | Response to heat |
| Response to unfolded protein | |
| Kidney cortex-kidney medulla-liver-lung | Electron transport |
| Kidney cortex-kidney medulla-lung-spleen | Inflammatory response |
| Negative regulation of gluconeogenesis | |
| Negative regulation of lipoprotein lipase activity | |
| Positive regulation of fatty acid metabolism | |
| Positive regulation of signal transduction | |
| Kidney cortex-kidney medulla-liver-lung-spleen | Immune response |
Biological processes affected in two or more tissues independent of the absorbed dose. All processes had a p value < 0.05. Additional information is presented in Additional file 1.