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. 2011 Dec 5;108(51):20730–20735. doi: 10.1073/pnas.1108696108

Fig. 4.

Fig. 4.

DA directly and specifically up-regulates Ang1 expression in pericytes. (A) Confocal images showing up-regulation of Ang1 in pericytes following DA treatment of PC3 and HT29 tumors. Pretreatment with the DA D2 receptor antagonist eticlopride abrogates this effect of DA. Western blot analysis shows the expression of Ang1 in HBVP. (Scale bars, 50 μm.) (B) Treatment with DA (1 μM) or the DA D2 receptor agonist quinpirole (1 μM) significantly up-regulates Ang1 expression in HBVP. Treatment with the DA D1 receptor agonist SKF 38393 fails to up-regulate Ang1 expression in HBVP. (C) The effect of both DA and quinpirole (Quin) is lost after pretreatment with eticlopride (1 μM). Western blot shows the presence of DA D2 receptors in HBVP but not in control S180 cells. Results shown are representative of six separate experiments.