Fig. 1.

Ty1 retrotransposition levels and aging-associated increases in genome instability are frequently correlated. Relative mean (±SD) of median values for initial and aging-associated LOH and chromosome (chr) loss frequencies was calculated for the indicated WT and mutant strains using the data presented in Table 1. Relative retrotransposition for each mutant was determined using Ty1 integration PCR data, as described in SI Materials and Methods. All WT values were set to 1, and values for mutants were normalized to the corresponding WT value. A star over a bar for aging LOH or aging chr loss indicates P < 0.05 using a two-tailed t test assuming unequal variance.