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. 2011 Nov 2;108(51):20784–20789. doi: 10.1073/pnas.1116795108

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Fig. 4. — Replacing A1 with A2 changes gating energies and a portion of RCK1. (A) Change in free energy, ΔΔG, conferred by replacing A1 with A2. Each bar was computed from zV_1/2 for the A1-type and A2-type splice variants with the indicated composition at sites B and C. Errors were propagated from the SD of zV_1/2 in the relevant A1-type and A2-type splice variants. (B) SLO-1(A1;B1;C0) homology model threaded to the human BK channel cytoplasmic domain crystal structure (3MT5). RCK domains are shown in gray, the Ca²⁺ bowl is red, and the region encoded by A1 (α-H, β-G, and α-I) is shown in blue. (C) Same as in B, except showing SLO-1(A2;B0;C0) with the region encoded by A2 shown in blue.