Fig. 2.

Overall structure of PRMT5. (A) A ribbon representation of PRMT5 monomer. Domains are colored as in Fig. 1A. Helices and strands are labeled TA to TH and T1 to T8, respectively, for the TIM-barrel domain; αA to αF and β1 to β5, respectively, for the Rossmann-fold domain; and OA-OB and O1-O2, respectively, for the oligomerization domain. Strands in the β-barrel domain are labeled b1 to b10. L0 indicates the N-terminal loop of the Rossmann-fold domain, and the SAH molecule is shown in a stick model. (B) A PRMT5 dimer is shown as a ribbon model superimposed onto a surface representation. The surface for one monomer is colored light green and the other in light blue. The red line approximately traces the dimeric interface.