Table 1.

Thermodynamic parameters describing the reactions governing the Na⁺ deeply occluded state

		ΔH≠ kcal/mol	ΔS≠ cal/molK	ΔG≠ kcal/mol	Net ΔH kcal/mol	Net ΔScal/mol K	Net ΔG kcal/mol
Soc↔S3	deocclusion	23.6 ± 1.5	61.8 ± 5.1	5.5 ± 1.7	19.6	62.4	1.2 ± 1.5
	occlusion	(4.1 ± 1.3)	(−0.6 ± 4.5)	4.3 ± 0.1
Binding/unbinding S3↔S2K(0) = 7.74 ± 0.6					−11.4 ± 3.5	−34.7 ± 12	−1.2 ± 3.5
Combined Soc↔S2					8.4	27.7	0 ± 3.8