Table 2.
Proinflammatory allele of FCAR associates with renal involvement in GPA
| Genotype |
Allele |
||||
| Cases | AA | AG | GG | A | G |
| WEGGER | |||||
| No renal involvement | 149 (78.4%) | 38 (20%) | 3 (1.6%) | 336 (88.4%) | 44 (11.6%) |
| Renal involvement | 171 (67.1%) | 77 (30.2%) | 7 (2.7%) | 419 (82.1%) | 91 (17.8%) |
| All cases | 320 (71.9%) | 115 (25.8%) | 10 (2.2%) | 755 (84.8%) | 135 (15.2%) |
| Controls | 249 (60.3%) | 149 (36.1%) | 15 (3.6%) | 647 (78.3%) | 179 (21.7%) |
| VCRC | |||||
| No renal involvement | 83 (83.8%) | 13 (13.1%) | 3 (3.0%) | 179 (90.4%) | 19 (9.6%) |
| Renal involvement | 55 (59.8%) | 34 (37.0%) | 3 (3.3%) | 144 (78.3%) | 40 (21.7%) |
| All cases | 135 (71.1%) | 49 (25.8%) | 6 (3.2%) | 319 (83.9%) | 61 (16.1%) |
| WGGER and VCRC | |||||
| No renal involvement | 232 (80.3%) | 51 (17.6%) | 6 (2.7%) | 515 (89.1%) | 63 (10.9%) |
| Renal involvement | 226 (65.1%) | 111 (32.0%) | 10 (2.9%) | 563 (81.1%) | 131 (18.9%) |
| All cases | 455 (71.7%) | 164 (25.8%) | 16 (2.5%) | 1074 (84.6%) | 196 (14.4%) |
| HapMap Caucasians | 75 (66.4%) | 32 (28.3%) | 6 (5.3%) | 182 (80.5%) | 44 (19.5%) |
The FCAR G allele (rs16986050), functionally related to proinflammatory neutrophil responses, associates with predisposition for renal involvement. All samples were genotyped using an Illumina GoldenGate BeadXpress system for WGGER and Pyrosequencing for VCRC. Sixty-seven patients with GPA were enrolled in both studies and have been excluded from the VCRC dataset here.