Table 1.
Ex vivo biodistribution of radioactivity in atherosclerotic LDLR-/-ApoB100/100 and C57BL/6N control mice
|
LDLR
-/-
/ApoB
100/100
(n = 9, urine n = 8) |
C57BL/6N (n = 6, urine n = 5) |
p value | |
|---|---|---|---|
| Aorta | 1.99 ± 0.73 | 1.52 ± 0.40 | NSa |
| Bladder | 2.50 ± 0.62 | 1.92 ± 0.29 | NS |
| Blood | 8.60 ± 1.29 | 8.07 ± 0.55 | NS |
| Bone | 2.25 ± 0.50 | 4.08 ± 0.49 | < 0.05 |
| Fat | 0.46 ± 0.21 | 0.51 ± 0.07 | NS |
| Heart | 1.26 ± 0.26 | 1.29 ± 0.20 | NS |
| Intestine | 2.71 ± 0.70 | 3.16 ± 0.36 | NS |
| Kidney | 4.07 ± 0.78 | 4.25 ± 0.33 | NS |
| Liver | 2.69 ± 1.14 | 8.34 ± 4.33 | < 0.05 |
| Lungs | 3.28 ± 1.10 | 3.58 ± 0.33 | NS |
| Lymph nodes | 2.03 ± 0.51 | 2.35 ± 0.34 | NS |
| Muscle | 0.71 ± 0.24 | 0.71 ± 0.08 | NS |
| Pancreas | 1.21 ± 0.25 | 1.48 ± 0.21 | NS |
| Spleen | 3.20 ± 1.28 | 4.51 ± 1.63 | NS |
| Thymus | 1.89 ± 0.96 | 1.18 ± 0.15 | NS |
At 3 h after intravenous injection of ionic 68Ga. Results are expressed as % IA/g (mean ± SD). NS, not significant. aDifference between atherosclerotic and control mice.