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. Author manuscript; available in PMC: 2012 Jan 4.
Published in final edited form as: Biochemistry. 2010 May 4;49(17):3743–3752. doi: 10.1021/bi100135d

Figure 1. Octasaccharide compositional distribution in library versus ATIII bound fractions.

Figure 1

A. Heparin.

B. Heparan Sulfate

Each composition is given under the following format [ΔHexA, HexA, GlcN, SO3, Ac]. The insets show the base peak chromatograms of the LC/MS.

The change in the distribution of compositions that occurs after the affinity enrichment protocol indicates that in the heparin library most compositions contain high affinity binders whereas in HS some compositions are better binders than other. The compositions of heparin versus HS dp8 that bind ATIII differ dramatically; the sets of binding compositions in heparin versus HS are mutually exclusive.