Table 6.

—Key Research Priorities for Critical Care: Clinical Research

1.	Develop methods for the rapid, early recognition of acute, severe disease in patients at high risk for imminent deterioration.
2.	Develop minimally invasive, biocompatible organ support.
3.	Focus on therapeutic manipulation of the neuro-inflammatory state.
4.	Explore new approaches that enhance patient comfort while reducing the need to manipulate consciousness.
5.	Develop clinically accessible approaches to accelerate global system and organ recovery/reanimation.
6.	Identify the best process and outcome measurements for critical illness research and palliative and end-of-life care.