Table 2. Liver steatosis in mice fed high-carbohydrate diet or high fat diet for 46 weeks.

	CPT-1a+/+ (HCD)	CPT-1a+/− (HCD)	CPT-1a+/+ (HFD)	CPT-1a+/− (HFD)
Macrovesicular fat	3.5±3.9	4.7±3.3	2±2.2	1.9±1.5
Microvesicular fat	2.4±4.2	10.1±10*	2.3±3.6	6.5±7.9*
Total	5.9±7.6	14.8±9.6*	4.3±4.9	8.5±7.3*

Abbreviations: CPT, carnitine palmitoyltransferase; HCD, high-carbohydrate diet; HFD, high-fat diet.

CPT-1a+/− (n=22), CPT-1a+/+ (n=21) mice fed either diet demonstrated significantly higher total (macro plus microvesicular combined) fatty change (P=0.01) as compared with CPT-1a+/+ controls. Microvesicular fat was significantly higher in CPT-1a+/− mice when fed either diet as compared with CPT-1a+/+ mice (P=0.03). Microvesicular fat was significantly greater than macrovesicular fat in mice fed the HCD, independent of genotype (P=0.003).