Table 2.

miR-181, miR-181 antagomir and 3′UTR of HSPA5 and their seed mutants or mismatch sequences

	Wild Type (5′ to 3′)	Seed Mutant or Miss Match (5′ to 3′)
miR-181a	AACAUUCAACGCUGUCGGUGAGU	AUGUUAGUACGCUGUCGGUGAGU
miR-181b	AACAUUCAUUGCUGUCGGUGGGU	AUGUAAGUUUGCUGUCGGUGGGU
miR-181c	AACAUUCAACCUGUCGGUGAGU	AAGUGAGUUCCUGUCGGUGAGU
miR-181d	AACAUUCAUUGUUGUCGGUGGGU	AUGUAAGUAUGUUGUCGGUGGGU
miR-181a	soAsoCoUoCoAoCoCoGoAoCoAoGo	soAsoGoUoCoAoGoCoGoAoGoAoGo
Antagomir*	CoGoUoUoGoAoAoUsoGsoUsoUs-chol	CoCoUoUoGoAoUoUsoGsoUsoUs-chol
HSPA5	G-UCUCGAAUGUAA-UU	G-UCUCCUUACAAA-UU

^*From Alnylam Pharmaceuticals (Cambridge, MA, USA). oN = 2′-O-Methyl nucleotide; s = phosphorothioate linkage