Table 1.
Characteristic | Iloprost (n = 75) | Placebo (n = 77) | Iloprost: former smoker (n = 35) | Placebo: former smoker (n = 36) | Iloprost: current smoker (n = 40) | Placebo: current smoker (n = 41) |
---|---|---|---|---|---|---|
Sex of subject–No. (%) | ||||||
Female | 23 (30.7) | 19 (24.7) | 8 (22.9) | 9 (25.0) | 15 (37.5) | 10 (24.4) |
Male | 52 (69.3) | 58 (75.3) | 27 (77.1) | 27 (75.0) | 25 (62.5) | 31 (75.6) |
Race of subject–No. (%) | ||||||
Black | 4 (5.3) | 8 (10.4) | 0 (0.0) | 3 (8.3) | 4 (10.0) | 5 (12.2) |
Other | 2 (2.7) | 3 (3.9) | 1 (2.9) | 0 (0.0) | 1 (2.5) | 3 (7.3) |
White | 69 (92.0) | 66 (85.7) | 34 (97.1) | 33 (91.7) | 35 (87.5) | 33 (80.5) |
Age, y | 57.6 ± 10.6 | 58.3 ± 8.6 | 61.5 ± 10.7 | 61.2 ± 9.6 | 54.2 ± 9.2 | 55.7 ± 6.8 |
Smoker years | 34.6 ± 10.5 | 36.0 ± 10.0 | 32.3 ± 10.1 | 33.0 ± 10.2 | 36.6 ± 10.5 | 38.7 ± 9.0 |
Packs per day | 1.5 ± 0.6 | 1.4 ± 0.5 | 1.8 ± 0.7 | 1.4 ± 0.5 | 1.3 ± 0.4 | 1.3 ± 0.6 |
Pack years | 51.8 ± 26.8 | 49.9 ± 26.3 | 56.4 ± 29.6 | 48.7 ± 27.0 | 47.8 ± 23.7 | 50.9 ± 26.0 |
Smoker quit years | 12.0 ± 8.4 | 12.0 ± 10.0 | ||||
FEV1 | 2.4 ± 0.9 | 2.3 ± 1.0 | 2.4 ± 0.9 | 2.3 ± 1.0 | 2.5 ± 0.9 | 2.4 ± 0.9 |
FEV/FVC ratio | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.2 | 0.7 ± 0.1 | 0.7 ± 0.1 |
Sputum cytology | 4.4 ± 0.7 | 4.4 ± 0.6 | 4.4 ± 0.6 | 4.3 ± 0.5 | 4.4 ± 0.8 | 4.5 ± 0.7 |
Average histology | 2.6 ± 1.1 | 2.5 ± 1.1 | 2.1 ± 1.0 | 2.0 ± 1.1 | 3.0 ± 1.1 | 2.9 ± 0.9 |
Maximum histology | 4.3 ± 1.5 | 3.8 ± 1.6 | 3.6 ± 1.8 | 3.1 ± 1.8 | 4.8 ± 0.9 | 4.5 ± 1.1 |
Dysplasia index | 33.3 ± 28.7 | 32.8 ± 31.1 | 20.4 ± 22.2 | 21.3 ± 28.5 | 44.6 ± 29.2 | 42.8 ± 30.1 |
Maximum histology–No. (%) | ||||||
No dysplasia (grades 1–3) | 16 (21.3) | 22 (28.6) | 13 (37.1) | 18 (50.0) | 3 (7.5) | 5 (12.2) |
Mild (grade 4) | 14 (18.7) | 15 (19.5) | 7 (20.0) | 5 (13.9) | 7 (17.5) | 10 (24.4) |
Moderate (grade 5) | 33 (44.0) | 35 (45.5) | 10 (28.6) | 12 (33.3) | 23 (57.5) | 23 (56.1) |
Severe (grade 6) | 12 (16.0) | 4 (5.2) | 5 (14.3) | 1 (2.8) | 7 (17.5) | 3 (7.3) |
Plus-minus values are means ± SD.