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. 2011 Sep 28;302(1):F192–F204. doi: 10.1152/ajprenal.00562.2010

Fig. 3.

Fig. 3.

Mast cell-deficient (MCD) mice do not develop tubulointerstitial fibrosis with 14-day UUO. A: representative section of Masson's trichrome-stained 14-day UUO kidney from a congenic control (CC) mouse. Collagen is stained blue. Scale bar = 50 μm. B: representative section of Masson's trichrome-stained 14-day UUO kidney from a MCD mouse. Note the lack of collagen (blue) staining. Scale bar = 50 μm. C: graph of mean percentage of collagen (±SE) per area of tissue as analyzed by spectral separation in trichrome-stained sections of UUO kidneys from CC (n = 4) and MCD (n = 3) mice. UUO kidneys from CC mice have significantly more (*P < 0.05) collagen-stained areas than UUO kidneys from MCD mice.