Figure 4. Target-dependent differences in short-term facilitation and PTP.

Paired-pulse facilitation (A, B), enhancement during stimulus trains (C, D), and PTP (E, F) following stimulus trains (10 stimuli at 50 Hz) were examined at PF synapses onto PCs (black) and GCs (red). EPSCs were recorded in voltage-clamp with a Cs-based internal solution in the presence of GABA_AR, GABA_BR, and CB1R antagonists. Summaries of experiments examining each form of plasticity (A, n = 6 PCs and GCs; C, n = 13 PCs and GCs; E, n = 12 PCs and GCs) and representative experiments (B, D, F) are shown.