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. 2012 Jan 4;7(1):e29598. doi: 10.1371/journal.pone.0029598

Figure 1. Testosterone deficiency causes senescence of hippocampus and cognitive impairment in SAMP8 mice.

Figure 1

A. Body weight, appearance, and plasma testosterone level of male SAMR1 and SAMP8 mice at 12 weeks of age. B. Escape latency of SAMR1 (N = 10) and SAMP8 mice (N = 10). Male mice were treated daily for 2 weeks with DHT (500 µg s.c) before trials. Swim speed during quadrant test on day 10. C. Total distance and the ratio of central/total distance were measured in open field tests. D. Number of amyloid ß plaques, pyramidal cells, and SA-ßgal-positive cells in CA1 and CA3 areas of hippocampus in SAMR1 and SAMP8. (*p<0.05, n.s: not significant).