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. Author manuscript; available in PMC: 2012 Jan 4.
Published in final edited form as: J Biol Chem. 2004 Nov 12;280(3):2002–2011. doi: 10.1074/jbc.M406509200

Fig. 7. Plots of the therapeutic indices (A) and the antibiotic (B, upper line) and hemolytic activities (B, lower line) of GS14 and its lysine diastereomers as a function of the retention times of the peptides on a RP-HPLC column.

Fig. 7

Antibiotic activities were measured against A. laidlawii B and are expressed as the negative logarithm of the apparent LD50 values determined from the data presented in Fig. 6. The hemolytic activity data were obtained from Ref. 8. The therapeutic indices are the ratios between the apparent LD50 values for inhibition of A. laidlawii B growth and the hemolytic activity and are thus a gauge of the capacity of these peptides to discriminate between A. laidlawii B cells and erythrocytes. The symbols represent data points obtained with the following peptides: GS14 (■), GS14dK2 (△), GS14dK4 (○), GS14dK9 (◆), GS14dK11 (☆), GS14dK2K4 (*), and GS14dK2K4K9K11 (▲).