Table II.
Comparison of the assayed properties of GS14 and its diastereomeric analogs
| Assayed property | As deduced from | Ranking order | Ref. |
|---|---|---|---|
| β-Sheet content in H2O | CD | GS14 ≫ dK11 > dK4 > dK9 > dK2 ≫ dK2K4 > dK2K4K9K11 | This work |
| β-Sheet content in membrane mimetic media | CD | GS14 ≫ dK11 > dK4 > dK9 ≥ dK2 ≫ dK2K4 > dK2K4K9K11 | This work |
| Facial amphiphilicity | RP-HPLC | GS14 ≫ dK2 > dK9 > dK4 > dK11 ≫ dK2K4 > dK2K4K9K11 | This work |
| Self-association | RP-HPLC | GS14 ≫ dK2 > dK9 > dK4 > dK11 ≫ dK2K4 > dK2K4K9K11 | This work |
| Aqueous solubility | RP-HPLC | dK2K4K9K11 ≫ dK2 K4 ≫ dK11 > dK4 > dK9 > dK2 > GS14 | This work |
| Cubic phase induction | 31P NMR | GS14 ≫ dK11 > dK4 > dK2 > dK9 ≫ dK2K4K9K11 > dK2K4 | This work |
| Membrane lysis | Calcein dye leakage from POPC vesicles | GS14 ≫ dK4 > dK11 > dK2 > dK9 ≫ dK2K4 > dK2K4K9K11 | This work |
| LPS binding affinity | Dansyl polymixin B displacement | GS14 ≫ dK2 ~ dK11 > dK9 > dK4 ≫ dK2K4 > dK2K4K9K11 | 8 |
| Antibiotic activity | A. laidlawii B | GS14 ≫ dK4 > dK2 > dK11 ~ dK9 ≫ dK2K4 > dK2K4K9K11 | This work |
| Antibiotic activity | Gram-negative bacteria | dK4 > dK11 > dK9 > dK2 ≫ dK2K4 > GS14 ~ dK2K4K9K11 | 8 |
| Antibiotic activity | Gram-positive bacteria | dK11 > dK4 > dK9 > dK2 ≫ GS14 ≫ dK2K4 > dK2K4K9K11 | 8 |
| Antibiotic activity | Fungal growth | GS14 > dK11 ~ dK2 > dK4 ~ dK9 > dK2K4 > dK2K4K9K11 | 8 |
| Hemolytic activity | Human erythrocyte lysis | GS14 ≫ dK2 > dK9 > dK11 > dK4 ≫ dK2K4 > dK2K4K9K11 | 8 |
| Therapeutic indices | Hemolytic, antifungal, and antibacterial activities | dK4 > dK11 ≫ dK9 > dK2 ≫ dK2K4 > dK2K4K9K11 ≫ GS14 | 8 |