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Published in final edited form as: Eur J Neurosci. 2011 Nov 25;35(1):160–165. doi: 10.1111/j.1460-9568.2011.07929.x

A. Cannula placements for rats in Experiment 3. Numerals on the left indicate distance (mm) from Bregma. Medial prefrontal cortex (mPFC) placements were considered successful if they terminated within the infralimbic (IL) and prelimbic (PL) cortices. Not all cannula are shown due to overlapping placements. B. Intra-mPFC muscimol blocks behavioral immunization to potentiation of morphine conditioned place preference (CPP) when escapable tailshock (ES) and inescapable tailshock (IS) are separated by 24 hours. Data are expressed as mean + SEM difference of time (sec) spent in the morphine-paired environment before and after conditioning. Positive scores indicate a shift in preference for the morphine-paired environment. #The saline-HC/IS group was significantly different from the saline-ES/IS & saline-HC/HC groups (p < 0.05). *Muscimol-ES/IS was significantly different from saline-ES/IS (p < 0.05). ^The muscimol-HC/HC group was significantly different from the muscimol-ES/IS & muscimol-HC/IS groups (p < 0.05).

A. Cannula placements for rats in Experiment 3. Numerals on the left indicate distance (mm) from Bregma. Medial prefrontal cortex (mPFC) placements were considered successful if they terminated within the infralimbic (IL) and prelimbic (PL) cortices. Not all cannula are shown due to overlapping placements. B. Intra-mPFC muscimol blocks behavioral immunization to potentiation of morphine conditioned place preference (CPP) when escapable tailshock (ES) and inescapable tailshock (IS) are separated by 24 hours. Data are expressed as mean + SEM difference of time (sec) spent in the morphine-paired environment before and after conditioning. Positive scores indicate a shift in preference for the morphine-paired environment. #The saline-HC/IS group was significantly different from the saline-ES/IS & saline-HC/HC groups (p < 0.05). *Muscimol-ES/IS was significantly different from saline-ES/IS (p < 0.05). ^The muscimol-HC/HC group was significantly different from the muscimol-ES/IS & muscimol-HC/IS groups (p < 0.05).