Table 2.
The predicted off-targets and OTEs for the repositioned drugs on MCF7 breast cancer cell line
| Drugs | Off-targets | OTEs | ||||||
|---|---|---|---|---|---|---|---|---|
| Signaling pathway | Symbol | Entrez Gene Name | Location | Family | Entrez Gene ID | Target | Pathway | |
| raloxifene 0.1μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0433 | ↘ |
| E2F1 | E2F transcription factor 1 | Nucleus | transcription regulator | 1869 | −0.0268 | ↘ | ||
| E2F2 | E2F transcription factor 2 | Nucleus | transcription regulator | 1870 | −0.0206 | ↘ | ||
| E2F4 | E2F transcription factor 4, p107/p130-binding | Nucleus | transcription regulator | 1874 | −0.0392 | ↘ | ||
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | −0.0216 | ↘ | |
|
| ||||||||
| raloxifene 7.8μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0611 | ↘ |
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | 0.0274 | ↗ | |
|
| ||||||||
| tamoxifen 1μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0222 | ↘ |
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | 0.0178 | ↗ | |
| MDM2 | Mdm2 p53 binding protein homolog | Nucleus | transcription regulator | 4193 | −0.0115 | ↗ | ||
|
| ||||||||
| tamoxifen 7μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0185 | ↘ |
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | 0.0138 | ↗ | |
| MDM2 | Mdm2 p53 binding protein homolog | Nucleus | transcription regulator | 4193 | −0.0157 | ↗ | ||
|
| ||||||||
| paclitaxel 4.6μMol | Cell cycle G1/S p53 signaling pathway |
TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0583 | ↘ |
| RBL1 | retinoblastoma-like 1 (p107) | Nucleus | other | 5933 | 0.1404 | ↘ | ||
| CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | Nucleus | transcription regulator | 1030 | 0.0933 | ↘ | ||
| BTRC | beta-transducin repeat containing | Cytoplasm | enzyme | 8945 | 0.0905 | ↘ | ||
| TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | 0.083 | ↗ | ||
| MDM2 | Mdm2 p53 binding protein homolog | Nucleus | transcription regulator | 4193 | −0.0583 | ↗ | ||
|
| ||||||||
| paclitaxel 1μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0201 | ↘ |
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | 0.016 | ↗ | |
| MDM2 | Mdm2 p53 binding protein homolog | Nucleus | transcription regulator | 4193 | −0.0153 | ↗ | ||
|
| ||||||||
| fulvestrant 1μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.0192 | ↘ |
| E2F1 | E2F transcription factor 1 | Nucleus | transcription regulator | 1869 | −0.0134 | ↘ | ||
| E2F2 | E2F transcription factor 2 | Nucleus | transcription regulator | 1870 | −0.0184 | ↘ | ||
| E2F4 | E2F transcription factor 4, p107/p130-binding | Nucleus | transcription regulator | 1874 | −0.0142 | ↘ | ||
| CDK2 | cyclin-dependent kinase 2 | Nucleus | kinase | 1017 | −0.0192 | ↘ | ||
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | −0.0115 | ↘ | |
| MDM2 | Mdm2 p53 binding protein homolog | Nucleus | transcription regulator | 4193 | 0.01 | ↘ | ||
|
| ||||||||
| fulvestrant 0.01μMol | Cell cycle G1/S | TFDP1 | transcription factor Dp-1 | Nucleus | transcription regulator | 7027 | −0.016 | ↘ |
| E2F1 | E2F transcription factor 1 | Nucleus | transcription regulator | 1869 | −0.0446 | ↘ | ||
| E2F2 | E2F transcription factor 2 | Nucleus | transcription regulator | 1870 | −0.0405 | ↘ | ||
| E2F4 | E2F transcription factor 4, p107/p130-binding | Nucleus | transcription regulator | 1874 | −0.0842 | ↘ | ||
| CDK2 | cyclin-dependent kinase 2 | Nucleus | kinase | 1017 | −0.0395 | ↘ | ||
| p53 signaling pathway | TP53 | tumor protein p53 | Nucleus | transcription regulator | 7157 | −0.0567 | ↘ | |
| MDM2 | Mdm2 p53 binding protein homolog | Nucleus | transcription regulator | 4193 | 0.0298 | ↘ | ||