Skip to main content
. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Clin Cancer Res. 2011 Nov 16;18(1):290–300. doi: 10.1158/1078-0432.CCR-11-2260

Figure 2. In vitro radiosensitivity is modulated by p53 expression depending on TP53 classification.

Figure 2

(A) A panel of 38 HNSCC cell lines was sequenced for TP53 status and evaluated for radiosensitivity using standard clonogenic assays. Each cell line was then grouped by TP53 status, and the average clonogenic survival data for each group is shown. (B) The effect of stable inhibition of wild type p53 expression (shp53) on radiosensitivity in HN 30 and UMSCC1 17A cells. (C) The effect of forced expression of wild type, R175H, R282W, or C176F TP53 in p53 null UMSCC1 cells on radiosensitivity. (D) The effect of stable inhibition of p53 expression (shp53) on radiosensitivity in FADU and HN 31 cells (disruptive TP53).