Table 1.

Signature gene lists for keratinocytes inhibited for EGFR signaling and expressing either oncogenic Ras (A) or wildtype Ras (B). Downregulated genes are in green and upregulated in red. Values are relative to EGFR wild-type keratinocytes with oncogenic (A) or wild-type Ras (B).

Table 1A.
Gene	EGFRnull	Erlotinib	AG1478	PD153035
Downregulated
dual specificity phosphatase 1 (Dusp1)	−3.34999	−2.113999	−2.409	−2.659
thioredoxin domain containing 10 (Txndc10)	−3.208999	−2.964	−4.531	−2.412999
PREDICTED: neuregulin 1, transcript variant 2 (Nrg1)	−3.187999	−2.862	−2.984999	−2.765999
PREDICTED: E3 ubiquitin protein ligase, HECT domain containing, 1, transcript variant 6 (Edd1)	−1.807	−2.83999	−2.264	−1.831
Up Regulated
solute carrier family 30 (zinc transporter), member 1 (Slc30a1)	2.2675737	2.2522523	2.8248588	1.984127
surfeit gene 1 (Surf1)	2.2883295	2.1786492	1.8382353	2.1008403
Ubiquitin domain containing 1	2.3696682	2.6315789	3.5971223	2.5316455
inhibitor of DNA binding 2 (Id2)	2.7027027	4.950495	4.2553191	3.8167939
PREDICTED: RIKEN cDNA 4930458A03 gene (4930458A03Rik), mRNA.	2.8490028	3.076923	2.4752475	4.2194092
aldehyde oxidase 1 (Aox1)	2.7322404	2.9411765	2.7548209	2.5906736
RIKEN cDNA 2200002J24 gene (2200002J24Rik), mRNA.	2.8735632	3.4013605	3.78787878	2.3364485
RIKEN cDNA 6230410P16 gene (6230410P16Rik), transcript variant 2	2.8985507	2.7624309	2.5974026	2.7173913
fucosyltransferase 9 (Fut9)	3.030303	3.8910506	2.0746888	3.0674847
Tissue inhibitor of metalloproteinase 3	3.2679739	3.2051282	3.2258065	2.3419204
RIKEN cDNA 4921528I07 gene	3.2786885	3.5460992	3.1545741	3.7735849
synaptoporin (Synpr)	3.3670034	2.8011204	3.3444816	3.030303
testis specific gene A2 (Tsga2)	3.3670034	4.4247788	3.6630037	4.4247788
ATPase, Ca++ transporting, plasma membrane 3 (Atp2b3)	3.5335689	3.4482759	4.0650407	3.968254
interferon-induced protein 44 (Ifi44)	3.5335689	3.5714286	3.4246575	2.6041667
CD46 antigen, complement regulatory protein (Cd46)	3.6101083	4.3668122	3.8314176	3.90625
RIKEN cDNA 2310026E23 gene (2310026E23Rik), mRNA.	4.2016806	3.5842293	3.3898305	2.1881838
solute carrier family 16 (monocarboxylic acid transporters), member 12 (Slc16a12), mRNA.	5.1282051	5.0761421	6.2789447	3.703703
camello-like 1 (Cml1)	5.5555556	5.3475936	5.9171598	13.69863
ryanodine receptor 1, skeletal muscle (Ryr1)	3.7522278	3.2258065	3.6764706	3.4722222
F-box and leucine-rich repeat protein 13 (Fbxl13), mRNA.	11.6279069	5.1020408	10.2040816	5.4644808

Table 1B.
Gene	EGFR null	Erlotinib	AG1478	PD153035
Downregulated
tenascin C (Tnc), mRNA.	−41.87473	−9.9395794	−9.0436273	−6 7006022
chemokine (C-X-C motif) ligand 3 (Cxcl3), mRNA.	−12.4585	−6.0032651	−7.2140103	−5.4960882
serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1), mRNA.	−5.480587	−3.9510035	−4.261114	−3.6979597
dual specificity phosphatase 9 (Dusp9), mRNA.	−7.642714	−3.7126055	−6.4856947	−4.8857617
forkhead box D3 (Foxd3), mRNA.	−3.025117	−2.6639708	−2.8218732	−2.624347
Golgi integral membrane protein 4	−6.650365	−3.2812439	−3.4076097	−3.0076131
cell division cycle 6 homolog (S. cerevisiae) (Cdc6), transcript variant 2, mRNA.	−3.177363	−2.9617525	−3.3367854	−2.6737621
kinesin family member 11 (Kif11), mRNA.	−2.586524	−2.3925532	−2.801853	−2.1541163
Upregulated
BEN domain containing 7 (Bend7), mRNA.	2.986081	2.59399268	2.17177856	2.123838473
Transcribed locus	5.117288	2.62182163	2.62978239	2.357328025
RRN3 RNA polymerase I transcription factor homolog (yeast) (Rrn3), mRNA	4.179157	3.01058099	3.03574806	2.600699744
membrane-spanning 4-domains, subfamily A, member 13 (Ms4a13), mRNA.	10.55176	2.62303544	5.03417703	2.540895071
adenosine A3 receptor (Adora3), transcript variant 2, mRNA.	6.572833	3.02683959	3.77621258	3.789070049
Vacuolar protein sorting 13A (yeast)	2.670708	2.63874731	2.15684629	1.896646066
adrenergic receptor, alpha 2b (Adra2b), mRNA.	3.285338	3.01698624	3.86207003	2.693184117
LY6/PLAUR domain containing 6 (Lypd6), mRNA.	2.30441	2.1395848	2.13043367	2.320750995
engrailed 2 (En2), mRNA.	2.444314	2.30637466	2.00310682	2.242360614
somatostatin (Sst), mRNA.	3.569832	3.90594027	3.58261785	2.805393762
myosin light chain kinase 3 (Mylk3), mRNA.	1.791513	2.14708521	1.92247208	3.027817467