Table 1.
In spite of immune pathology, the neutralization response is generally higher and broader during infection than after immunization with gp120. |
Cross-neutralizing responses are slow to develop (months, years), slower than other Abs to both Gag and Env, but often directed to single, dominant epitopes. |
NAb titers are generally lower in patients with undetectable than in those with high viral loads. |
During clinical progression Ab levels to Gag, but not Env, decline. Absorption by Ag is not responsible. Are Gag and Env responses regulated differently? |
Ab, antibody; NAb, neutralizing antibody; Ag, antigen.